Conversion of dehydroepiandrosterone, pregnenolone, and progesterone by interstitial cell tumor tissue.
نویسندگان
چکیده
Steroid biosynthesis was studied in a spontaneous mouse interstitial cell tumor grown as a transplant in isologous male recipients. In timed incubations the tu mor tissue rapidly transformed dehydroepiandrosterone to androstenedione. The formation of testosterone, 11/îhydroxyandrostenedione, and 11/3-hydroxytestosterone proceeded at a slower rate. A conversion product with Chromatographie characteristics of 19-hydroxyandrostenedione was also found. Incubation of tumor tissue with equal weights of 'H-labeled pregnenolone and 14C-labeled progesterone resulted in formation of dual-
منابع مشابه
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عنوان ژورنال:
- Cancer research
دوره 30 3 شماره
صفحات -
تاریخ انتشار 1970